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KMID : 0043319970200050496
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Archives of Pharmacal Research
1997 Volume.20 No. 5 p.496 ~ p.500
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Antioxidant Effect of Salvia miltiorrhiza
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Kang Hye-Sook
Chung Hae-Young
Jung Jee-Hyung
Kang Sam-Sik
Choi Jae-Sue
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Abstract
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A strong antioxidant activity, which was measured by the radical scavenging effect on 1, 1-diphenyl-2-picrylhydrazyl(DPPH) radical, was detected in the methanol extract of Salvia miltiorrhiza Bunge (Labiatae). By activity-directed fractionation, compounds 1 and 2 were isolated as antioxidant principles of S. miltiorrhiza. Compounds 1 and 2 were identified as dimethyl lithospermate and 3-(3, 4-dihydroxyphenyl)lactamide, respectively, on the basis of spectral data. The radical scavenging effect of compounds 1 and 2 on DPPH radical exceeded that of L-ascorbic acid which is a well known antioxidant. These two compounds also showed prominent inhibitory activity against free radical generation in dichlorofluorescein (DCF) method and cytoprotective effect against t-BHP in cultured liver cell.
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KEYWORD
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Salvia miltiorrhiza, dimethyl lithospermate, 3-(3, 4-dihydroxyphenyl)lactamide, antiozidant activity
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